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Akt1 is required for cell growth and survival in a mammalian organism. Shown here is a hematoxylin/eosin (H&E) stained section of a seminiferous tubule from a five-week-old Akt1
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mouse. As visualized by H&E staining, the arrangement of the normal layer of differentiating germ cells is disturbed, the thickness of germ cells in the tubules is uneven, and multinucleated giant cells are present in the lumen. Akt1
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mice also display increased spontaneous apoptosis in the testes and thymi as compared to wild-type littermates. (For details, see Chen et al., p. 2203.)