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GLD-1 acts as a translational repressor of rme-2 yolk receptor mRNA during C. elegans germ cell development. Shown here is an immunofluorescence analysis of a wild-type, adult hermaphrodite gonad that was dissected and stained for DNA (inset, right, blue), GLD-1 (inset, left, green), RME-2 (inset, left, red) and yolk (inset, left, purple). RME-2 is absent from early meiotic prophase germ cells distal to the loop where GLD-1 is abundant in the cytoplasm. RME-2 increases in abundance in growing oocytes proximal to the loop where GLD-1 levels fall precipitously and become undetectable. Yolk is accumulated only in the 3-4 most proximal oocytes. (For details, see Lee and Schedl, p. 2408.)