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Intercellular signals regulate pancreas development and function. Shown here as an inset are human pancreatic ductal cells migrating on a basal membrane-like matrix. The migrating cells are immunostained for F-actin (red),
v
-3 integrin (green), and
v
-5 integrin (blue). The background shows a polymer corrosion case of adult mouse pancreas, revealing the ductal and ductular branching morphology. (For details, see review by Kim and Hebrok, p. 111.) Confocal inset image appears courtesy of Dr. Vincenzo Cirulli; background image appears courtesy of A. Zhang and S.K. Kim.