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A conditional murine model of pulmonary adenocarcinoma reveals a role for K-Ras in lung tumorigenesis in the presence and absence of tumor suppressor genes. Shown here in the background is a TUNEL staining demonstrating apoptotic tumor cells following de-induction of mutant K-Ras in a tetracycline-regulated model of K-Ras-driven lung adenocarcinoma. Inset is a transverse MRI image demonstrating diffuse lung tumors in the same mouse. (For details, see Fisher et al., p. 3249; also see related paper by Jackson et al., p. 3243.)