Genes & Development -- Table of Contents (February 1 2001, 15 [3])

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Volume 15, Issue 3: February 1, 2001 [Index by Author] [Cover Caption]

Other Issues:

Research Communications

Research Papers

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Research Communications:

Eldad Tzahor and Andrew B. Lassar: Wnt signals from the neural tube block ectopic cardiogenesis
Genes Dev. 2001 15: 255-260. [Abstract] [Full Text] [PDF]

Hailan Zhang, Michael Levine, and Hilary L. Ashe: Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo
Genes Dev. 2001 15: 261-266. [Abstract] [Full Text] [PDF]

Research Papers:

Heiko Müller, Adrian P. Bracken, Richard Vernell, M. Cristina Moroni, Fred Christians, Emanuela Grassilli, Elena Prosperini, Elena Vigo, Jonathan D. Oliner, and Kristian Helin: E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
Genes Dev. 2001 15: 267-285. [Abstract] [Full Text] [PDF] Supplemental Research Data

Martin Wagner, Florian R. Greten, Christoph K. Weber, Stefan Koschnick, Torsten Mattfeldt, Wolfgang Deppert, Horst Kern, Guido Adler, and Roland M. Schmid: A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
Genes Dev. 2001 15: 286-293. [Abstract] [Full Text] [PDF]

Amanda E. Vandenberghe, Thomas H. Meedel, and Kenneth E.M. Hastings: mRNA 5'-leader trans-splicing in the chordates
Genes Dev. 2001 15: 294-303. [Abstract] [Full Text] [PDF]

Valerie A. Schneider and Mark Mercola: Wnt antagonism initiates cardiogenesis in Xenopus laevis
Genes Dev. 2001 15: 304-315. [Abstract] [Full Text] [PDF]

Martha J. Marvin, Giuliana Di Rocco, Aaron Gardiner, Sara M. Bush, and Andrew B. Lassar: Inhibition of Wnt activity induces heart formation from posterior mesoderm
Genes Dev. 2001 15: 316-327. [Abstract] [Full Text] [PDF]

Derek J. Richard, Valérie Schumacher, Brigitte Royer-Pokora, and Stefan G.E. Roberts: Par4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1
Genes Dev. 2001 15: 328-339. [Abstract] [Full Text] [PDF]

Christine Rushlow, Pamela F. Colosimo, Meng-chi Lin, Mu Xu, and Nikolai Kirov: Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs
Genes Dev. 2001 15: 340-351. [Abstract] [Full Text] [PDF]

Ryuichi Nishihama, Masaki Ishikawa, Satoshi Araki, Takashi Soyano, Tetsuhiro Asada, and Yasunori Machida: The NPK1 mitogen-activated protein kinase kinase kinase is a regulator of cell-plate formation in plant cytokinesis
Genes Dev. 2001 15: 352-363. [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Inhibiting Wnt signals in vivo directs anterior paraxial mesodermal cells into the cardiac fate. Shown here are whole-mountin situ hybridization analyses for ventricular myosin heavy chain(vMHC) expression in stage 12 chick embryos. At stage 7 the presumptiveanterior paraxial mesoderm of each embryo was implanted with cellpellets expressing BMP-4 plus the Wnt antagonist Frzb-IgG (right),or BMP-4 plus control IgG (left). The anterior paraxial mesodermis normally fated to give rise to the presumptive head mesenchyme.Whereas implantation of cells expressing only BMP-4 failed toaffect subsequent vMHC expression (left), implantation of cellsexpressing BMP-4 plus Frzb-IgG resulted in increased vMHC stainingin an enlarged heart (right). In addition, heart looping was reversedin over 50% of embryos containing the BMP-4 plus Frzb-IgG pellets(right). These results suggest that Wnt signals from the neuraltube normally repress ectopic cardiogenesis in the anterior paraxialmesoderm. (For details, see Tzahor et al., p. 255; see relatedarticles by Schneider et al., p. 304 and Marvin et al., p. 316.)