|
|
|
![]() Other Issues: |
|
||||||||
Exogenous expression of the PPAR
2 isoform, but not the
1 isoform, restores adipogenesis in preadipocytes deficient in PPAR
. Shown here are Oil Red O stained PPAR
deficient mouse adipogenic cells infected with retroviruses expressing PPAR
2. As visualized by the Oil Red O staining, PPAR
2 is sufficient to drive cellular lipid accumulation (dark red), the marker of adipogenesis, in cells engineered to lack both PPAR
isoforms. (For details, see Ren et al., p. 27; also see related paper by Rosen et al., p. 22.)