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Exogenous expression of the PPAR2 isoform, but not the 1 isoform, restores adipogenesis in preadipocytes deficient in PPAR. Shown here are Oil Red O stained PPAR deficient mouse adipogenic cells infected with retroviruses expressing PPAR2. As visualized by the Oil Red O staining, PPAR2 is sufficient to drive cellular lipid accumulation (dark red), the marker of adipogenesis, in cells engineered to lack both PPAR isoforms. (For details, see Ren et al., p. 27; also see related paper by Rosen et al., p. 22.)