Genes & Development -- Table of Contents (June 15 2002, 16 [12])

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Volume 16, Issue 12: June 15, 2002 [Index by Author] [Cover Caption]

Other Issues:

Perspectives

Reviews

Research Communications

Research Papers

Errata

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Perspectives:

William G. Kaelin, Jr.: How oxygen makes its presence felt
Genes Dev. 2002 16: 1441-1445. [Full Text] [PDF]

Reviews:

David M. Ornitz and Pierre J. Marie: FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
Genes Dev. 2002 16: 1446-1465. [Full Text] [PDF]

Research Communications:

David Lando, Daniel J. Peet, Jeffrey J. Gorman, Dean A. Whelan, Murray L. Whitelaw, and Richard K. Bruick: FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
Genes Dev. 2002 16: 1466-1471. [Abstract] [Full Text] [PDF]

Research Papers:

Diane C. Fingar, Sofie Salama, Christina Tsou, Ed Harlow, and John Blenis: Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
Genes Dev. 2002 16: 1472-1487. [Abstract] [Full Text] [PDF]

Catherine S. Lee, Nathalie Perreault, John E. Brestelli, and Klaus H. Kaestner: Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity
Genes Dev. 2002 16: 1488-1497. [Abstract] [Full Text] [PDF]

Jeffrey H. Stear and Mark B. Roth: Characterization of HCP-6, a C. elegans protein required to prevent chromosome twisting and merotelic attachment
Genes Dev. 2002 16: 1498-1508. [Abstract] [Full Text] [PDF] Supplemental Research Data

Yan-Fen Hu and Rong Li: JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction
Genes Dev. 2002 16: 1509-1517. [Abstract] [Full Text] [PDF]

Huck Hui Ng, Qin Feng, Hengbin Wang, Hediye Erdjument-Bromage, Paul Tempst, Yi Zhang, and Kevin Struhl: Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association
Genes Dev. 2002 16: 1518-1527. [Abstract] [Full Text] [PDF]

Kunheng Luo, Miguel A. Vega-Palas, and Michael Grunstein: Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast
Genes Dev. 2002 16: 1528-1539. [Abstract] [Full Text] [PDF]

Vesco J. Mutskov, Catherine M. Farrell, Paul A. Wade, Alan P. Wolffe, and Gary Felsenfeld: The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation
Genes Dev. 2002 16: 1540-1554. [Abstract] [Full Text] [PDF] Supplemental Research Data

Shravan Kumar Mishra, Joanna Tripp, Sybille Winkelhaus, Bettina Tschiersch, Klaus Theres, Lutz Nover, and Klaus-Dieter Scharf: In the complex family of heat stress transcription factors, HsfA1 has a unique role as master regulator of thermotolerance in tomato
Genes Dev. 2002 16: 1555-1567. [Abstract] [Full Text] [PDF]

Yikang S. Rong, Simon W. Titen, Heng B. Xie, Mary M. Golic, Michael Bastiani, Pradip Bandyopadhyay, Baldomero M. Olivera, Michael Brodsky, Gerald M. Rubin, and Kent G. Golic: Targeted mutagenesis by homologous recombination in D. melanogaster
Genes Dev. 2002 16: 1568-1581. [Abstract] [Full Text] [PDF]

Errata:

: Genes Dev. 2002 16: 1582. [Full Text] [PDF]

Cover Caption:

Cover

HCP-6 is required for normal mitotic chromosome condensation in C. elegans. Shown here is an immunofluorescence analysis ofa wild-type metaphase plate taken from a 4-cell C. elegans embryo,using antibodies directed against the centromeric histone HCP-3(pink) and DAPI (blue). Viewed from the centrosomal perspective,immunostaining reveals distinct lines of centromere staining,corresponding to sister centromeres on the twelve mitotic chromosomes(blue). A similar, opposing set of sister centromeres lies belowthe plane of the page. Chromosomes in the hcp-6 mutant twist aroundthe long axis of the chromosome, allowing single sister centromeresto be captured by microtubules from both poles. (For details,see Stear and Roth, p. 1498.)