Genes & Development -- Table of Contents (August 1 2002, 16 [15])

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Volume 16, Issue 15: August 1, 2002 [Index by Author] [Cover Caption]

Other Issues:

Perspectives

Research Communications

Research Papers

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Perspectives:

Aristidis Moustakas and Carl-Henrik Heldin: From mono- to oligo-Smads: The heart of the matter in TGF- $beta$ signal transduction
Genes Dev. 2002 16: 1867-1871. [Full Text] [PDF]

Satya Prakash and Louise Prakash: Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair
Genes Dev. 2002 16: 1872-1883. [Full Text] [PDF]

Research Communications:

Jason R. Kennerdell, Shinji Yamaguchi, and Richard W. Carthew: RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E
Genes Dev. 2002 16: 1884-1889. [Abstract] [Full Text] [PDF]

Research Papers:

Xiaozhong Wang, Hong Su, and Allan Bradley: Molecular mechanisms governing Pcdh- $gamma$ gene expression: Evidence for a multiple promoter and cis-alternative splicing model
Genes Dev. 2002 16: 1890-1905. [Abstract] [Full Text] [PDF]

Maike Stam, Christiane Belele, Jane E. Dorweiler, and Vicki L. Chandler: Differential chromatin structure within a tandem array 100 kb upstream of the maize b1 locus is associated with paramutation
Genes Dev. 2002 16: 1906-1918. [Abstract] [Full Text] [PDF]

Laura Maringele and David Lydall: EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70 $Delta$ mutants
Genes Dev. 2002 16: 1919-1933. [Abstract] [Full Text] [PDF]

Chia-Lun Tsai, Anna H. Drejer, and David G. Schatz: Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination
Genes Dev. 2002 16: 1934-1949. [Abstract] [Full Text] [PDF]

Bin Y. Qin, Suvana S. Lam, John J. Correia, and Kai Lin: Smad3 allostery links TGF- $beta$ receptor kinase activation to transcriptional control
Genes Dev. 2002 16: 1950-1963. [Abstract] [Full Text] [PDF]

Scott Barolo, Tammie Stone, Anne G. Bang, and James W. Posakony: Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
Genes Dev. 2002 16: 1964-1976. [Abstract] [Full Text] [PDF]

Yuying Liang, Jean Chang, Stephen J. Lynch, David M. Lukac, and Don Ganem: The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-J $kappa$ (CSL), the target of the Notch signaling pathway
Genes Dev. 2002 16: 1977-1989. [Abstract] [Full Text] [PDF]

Li Zeng, Hervé Kempf, L. Charles Murtaugh, Mie Elissa Sato, and Andrew B. Lassar: Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis
Genes Dev. 2002 16: 1990-2005. [Abstract] [Full Text] [PDF]

Takeshi Izawa, Tetsuo Oikawa, Nobuko Sugiyama, Takatoshi Tanisaka, Masahiro Yano, and Ko Shimamoto: Phytochrome mediates the external light signal to repress FT orthologs in photoperiodic flowering of rice
Genes Dev. 2002 16: 2006-2020. [Abstract] [Full Text] [PDF]

Da-Zhong Zhao, Guan-Fang Wang, Brooke Speal, and Hong Ma: The EXCESS MICROSPOROCYTES1 gene encodes a putative leucine-rich repeat receptor protein kinase that controls somatic and reproductive cell fates in the Arabidopsis anther
Genes Dev. 2002 16: 2021-2031. [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Phosphorylation-induced trimerization regulates Smad3 activity in the TGF- $beta$ signal transduction pathway. Shown here is a modelof the transforming growth factor beta (TGF- $beta$ ) receptor complex.The complex consists of the type I transmembrane receptor kinase(green), type II transmembrane receptor kinase (pink), TGF- $beta$ ligand(dark blue), SARA (yellow), and Smad 3 (subdomains colored cyanand red). Ligand binding triggers phosphorylation of the GS loopresidues (pink spheres) in the type I kinase by the type II kinase.The type I kinase then phosphorylates the Smad3 C-terminal tail(pink). Phosphorylation of Smad3 requires recruitment by SARA,as well as interactions between the Smad3 L3 loop residues (redspheres) and the type I kinase L45 loop residues (blue spheres).Upon phosphorylation, Smad3 undergoes conformational changes,which favor its dissociation from SARA. The ectodomain/ligandportion was modeled after recently published crystal structures.The cytoplasmic portion was derived from docking the kinase domainsto the crystal structure of a dimeric Smad3/SARA complex. (Fordetails, see Qin et al., p. 1950.)