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Meis homeoproteins regulate Pax6 expression during lens development. Shown here is a vibratome section of a whole mount in situ hybridization analysis of Meis1 mRNA in the embryonic day E10.5 mouse eye. Meis1 transcripts (blue) are strongly expressed in the invaginating lens vesicle, and at lower levels in the underlying optic vesicle. Meis1 and Pax6 expression colocalizes in lens vesicle (not shown). Meis1 and its closely related family member, Meis2, are homeoproteins that directly bind the Pax6 lens enhancer and control Pax6 expression during vertebrate lens induction. (For details, see Zhang et al., p. 2097.)