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A novel protein-coding gene, TAR1 (Transcript Antisense to Ribosomal RNA), is located on the antisense strand of the 25S ribosomal RNA gene in the rDNA repeat region of Chromosome XII in Saccharomyces cerevisiae. Shown here is an immunofluorescence analysis of DAPI-stained S. cerevisiae cells using antibodies directed against Tar1 (red), illustrating Tar1 localization to the mitochondria. The identification of TAR1 provides evidence that protein-coding and structural RNA sequences can overlap. (For details, see Coelho et al., p. 2755.)