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FGF18 is a perichondrial factor required for mouse skeletogenesis. Shown here is an in situ hybridization analysis of Fgf18 expression in the humeral growth plate of an E14.5 mouse embryo. Fgf18 transcripts (red) can be detected in the developing perichondrium. FGF18 signals through FGFR3 to negatively regulate chondrocyte proliferation and differentiation. FGF18 also signals through other FGFRs to regulate osteogenesis. (For details, see Liu et al., p. 859; also see related paper by Ohbayashi et al., p. 870.)