Genes & Development -- Table of Contents (January 1 2003, 17 [1])

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Volume 17, Issue 1: January 1, 2003 [Index by Author] [Cover Caption]

Other Issues:

Perspectives

Reviews

Research Communications

Research Papers

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Perspectives:

Clifford J. Tabin and Kyle J. Vogan: A two-cilia model for vertebrate left-right axis specification
Genes Dev. 2003 17: 1-6. [Full Text] [PDF]

Reviews:

Darren F. Seals and Sara A. Courtneidge: The ADAMs family of metalloproteases: multidomain proteins with multiple functions
Genes Dev. 2003 17: 7-30. [Full Text] [PDF]

Research Communications:

Simon K. Cheng, Felix Olale, James T. Bennett, Ali H. Brivanlou, and Alexander F. Schier: EGF-CFC proteins are essential coreceptors for the TGF- $beta$ signals Vg1 and GDF1
Genes Dev. 2003 17: 31-36. [Abstract] [Full Text] [PDF]

David G.T. Hesslein, David L. Pflugh, Dipanjan Chowdhury, Alfred L. M. Bothwell, Ranjan Sen, and David G. Schatz: Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments
Genes Dev. 2003 17: 37-42. [Abstract] [Full Text] [PDF]

Mariano Labrador and Victor G. Corces: Phosphorylation of histone H3 during transcriptional activation depends on promoter structure
Genes Dev. 2003 17: 43-48. [Abstract] [Full Text] [PDF]

Research Papers:

Guiliang Tang, Brenda J. Reinhart, David P. Bartel, and Phillip D. Zamore: A biochemical framework for RNA silencing in plants
Genes Dev. 2003 17: 49-63. [Abstract] [Full Text] [PDF]

Mihoko Kai and Teresa S.-F. Wang: Checkpoint activation regulates mutagenic translesion synthesis
Genes Dev. 2003 17: 64-76. [Abstract] [Full Text] [PDF]

Robert E. Johnson, Sung-Lim Yu, Satya Prakash, and Louise Prakash: Yeast DNA polymerase zeta ( $zeta$ ) is essential for error-free replication past thymine glycol
Genes Dev. 2003 17: 77-87. [Abstract] [Full Text] [PDF]

Sandy Chang, Christine M. Khoo, Maria L. Naylor, Richard S. Maser, and Ronald A. DePinho: Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression
Genes Dev. 2003 17: 88-100. [Abstract] [Full Text] [PDF] Supplemental Research Data

Mark L. McCleland, Richard D. Gardner, Marko J. Kallio, John R. Daum, Gary J. Gorbsky, Daniel J. Burke, and P. Todd Stukenberg: The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity
Genes Dev. 2003 17: 101-114. [Abstract] [Full Text] [PDF] Supplemental Research Data

Edan Foley and Patrick H. O'Farrell: Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila
Genes Dev. 2003 17: 115-125. [Abstract] [Full Text] [PDF]

Ariel A. Avilion, Silvia K. Nicolis, Larysa H. Pevny, Lidia Perez, Nigel Vivian, and Robin Lovell-Badge: Multipotent cell lineages in early mouse development depend on SOX2 function
Genes Dev. 2003 17: 126-140. [Abstract] [Full Text] [PDF] Supplemental Research Data

Nina Trokovic, Ras Trokovic, Petra Mai, and Juha Partanen: Fgfr1 regulates patterning of the pharyngeal region
Genes Dev. 2003 17: 141-153. [Abstract] [Full Text] [PDF] Supplemental Research Data

Cover Caption:

Cover

The vertebrate Ndc80 kinetochore complex is required for mitotic chromosome congression. Shown here is a prophase Xenopustissue culture cell that was microinjected with function-blockingantibodies directed against the Xenopus homolog of Ndc80 (xNdc80)in the presence of the proteasome inhibitor MG132. The cell wassubsequently fixed, treated with antibodies directed against tubulin(red), and stained with DAPI (blue) to visualize the DNA. Immunofluorescenceanalysis reveals that the unaligned chromosomes appear to floataround a normal mitotic spindle and fail to congress to form ametaphase plate. (For details, see McCleland et al. p. 101.)