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Drosophila salivary gland cells, which are several hundred times bigger than embryonic and imaginal disc cells, are capable of responding to Hedgehog signaling. Shown here are early third instar larval salivary gland cells taken from transgenic flies producing GFP-tagged Smoothened (GFP-Smo) and Hedgehog (Hh). Without added Hh, low amounts of GFP-Smo are located in a network of intracellular structures (not shown). In salivary gland cells where an active form of Hh signal (HhN) is produced, GFP-Smo (green) undergoes a dramatic translocation to the cell surface. 7AAD (red) is used as a nuclear marker. (For details, see Zhu et al., p. 1240.)