Genes & Development -- Table of Contents (August 1 2003, 17 [15])

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):
Year:		Vol:		Page:

Receive this page by email each issue: [Sign up for eTOCs]

Volume 17, Issue 15: August 1, 2003 [Index by Author] [Cover Caption]

Other Issues:

Perspectives

Research Communications

Research Papers

Find articles in this issue containing these words:
[Search ALL Issues]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Perspectives:

Jill A. Fahrner and Stephen B. Baylin: Heterochromatin: stable and unstable invasions at home and abroad
Genes Dev. 2003 17: 1805-1812. [Full Text] [PDF]

Eileen White: The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines
Genes Dev. 2003 17: 1813-1816. [Full Text] [PDF]

Research Communications:

Madeleine A. Palacios DeBeer, Ulrika Müller, and Catherine A. Fox: Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin
Genes Dev. 2003 17: 1817-1822. [Abstract] [Full Text] [PDF] Supplemental Research Data

Jinrong Min, Yi Zhang, and Rui-Ming Xu: Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27
Genes Dev. 2003 17: 1823-1828. [Abstract] [Full Text] [PDF]

Ken Inoki, Yong Li, Tian Xu, and Kun-Liang Guan: Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
Genes Dev. 2003 17: 1829-1834. Published in Advance July 17, 2003, 10.1101/gad.1110003 [Abstract] [Full Text] [PDF]

Per Lindblom, Holger Gerhardt, Stefan Liebner, Alexandra Abramsson, Maria Enge, Mats Hellström, Gudrun Bäckström, Simon Fredriksson, Ulf Landegren, Henrik C. Nyström, Göran Bergström, Elisabetta Dejana, Arne Östman, Per Lindahl, and Christer Betsholtz: Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
Genes Dev. 2003 17: 1835-1840. [Abstract] [Full Text] [PDF]

Research Papers:

Casey J. Fox, Peter S. Hammerman, Ryan M. Cinalli, Stephen R. Master, Lewis A. Chodosh, and Craig B. Thompson: The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
Genes Dev. 2003 17: 1841-1854. Published in Advance July 17, 2003, 10.1101/gad.1105003 [Abstract] [Full Text] [PDF]

Kasirajan Ayyanathan, Mark S. Lechner, Peter Bell, Gerd G. Maul, David C. Schultz, Yoshihiko Yamada, Kazuhiro Tanaka, Kiyoyuki Torigoe, and Frank J. Rauscher, III: Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation
Genes Dev. 2003 17: 1855-1869. Published in Advance July 17, 2003, 10.1101/gad.1102803 [Abstract] [Full Text] [PDF]

Wolfgang Fischle, Yanming Wang, Steven A. Jacobs, Youngchang Kim, C. David Allis, and Sepideh Khorasanizadeh: Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
Genes Dev. 2003 17: 1870-1881. [Abstract] [Full Text] [PDF]

Jae Hyung An and T. Keith Blackwell: SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
Genes Dev. 2003 17: 1882-1893. Published in Advance July 17, 2003, 10.1101/gad.1107803 [Abstract] [Full Text] [PDF]

Sanjay Vashee, Christin Cvetic, Wenyan Lu, Pamela Simancek, Thomas J. Kelly, and Johannes C. Walter: Sequence-independent DNA binding and replication initiation by the human origin recognition complex
Genes Dev. 2003 17: 1894-1908. [Abstract] [Full Text] [PDF]

Mariko Ariyoshi and John W.R. Schwabe: A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling
Genes Dev. 2003 17: 1909-1920. [Abstract] [Full Text] [PDF]

Roman V. Kondratov, Mikhail V. Chernov, Anna A. Kondratova, Victoria Y. Gorbacheva, Andrei V. Gudkov, and Marina P. Antoch: BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system
Genes Dev. 2003 17: 1921-1932. [Abstract] [Full Text] [PDF] Supplemental Research Data

Cover Caption:

Cover Cover Recruitment of heterochromatin protein 1 (HP1) to an expressed transgene in mammalian cells results in the epigenetically heritable silencing of the gene. Shown here is a fluorescence in situ hybridization (FISH) analysis of 4-OHT-treated mammalian cells that have been cotransfected with a PAX3KRAB-luciferase reporter transgene and a KRAB-PAX3-HBD (estrogen receptor hormone-binding domain) fusion protein. Treatment with the synthetic estrogen 4-OHT activates the KRAB fusion protein and, through an interaction between KAP1 and the KRAB-binding domain, targets a KAP1/HP1/SETDB1 protein complexto stably silence the luciferase transgene. FISH was carried out using a luciferase probe and the cells were counterstained with DAPI to visualize condensed heterochromatin (blue). In most cells, the luciferase FISH signals merge with the regions of condensed chromatin (lighter, bluish dots). (For details, see Ayyanathan et al., p. 1855.)