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Cover The kinetochore forms a dynamic interface with spindle microtubules to segregate chromosomes during mitosis.
Shown here are immunofluorescence images of the first mitotic division of the C. elegans embryo, in which the
kinetochores have been highlighted using antibodies to the newly identified kinetochore protein KNL-1 (green). Spindle
microtubules are labeled in red, and chromosomal DNA in blue. KNL-1 localizes to kinetochores throughout mitosis and
is required to translate the initiation of kinetochore assembly into the formation of a functional microtubule-binding
interface. (For details, see Desai et al., p. 2421.)