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Cover Structural insight into the interaction between
-catenin and the scaffolding protein Axin. Shown here is a crystal structure of the armadillo repeat region of human
-catenin (yellow) in complex with the
-catenin binding domain of Xenopus Axin (XAxin-CBD; red). The XAxin-CBD helix binds the groove formed by the third and fourth armadillo repeats of
-catenin and thereby prevents simultaneous binding by other
-catenin partners. Misexpression of components of this pathway in Xenopus embryos leads to duplication of the embryonic axis (background). (For details, see Xing et al., p. 2753.)