Genes & Development -- Table of Contents (December 15 2003, 17 [24])

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Volume 17, Issue 24: December 15, 2003 [Index by Author] [Cover Caption]

Other Issues:

Perspectives

Reviews

Research Communications

Research Papers

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Perspectives:

Joan Massagué: Integration of Smad and MAPK pathways: a link and a linker revisited
Genes Dev. 2003 17: 2993-2997. [Full Text] [PDF]

Reviews:

Charles L. Sawyers: Opportunities and challenges in the development of kinase inhibitor therapy for cancer
Genes Dev. 2003 17: 2998-3010. [Full Text] [PDF]

Research Communications:

Rui Yi, Yi Qin, Ian G. Macara, and Bryan R. Cullen: Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
Genes Dev. 2003 17: 3011-3016. Published in Advance December 17, 2003, 10.1101/gad.1158803 [Abstract] [Full Text] [PDF]

Mikhail Lomonosov, Shubha Anand, Mahesh Sangrithi, Rachel Davies, and Ashok R. Venkitaraman: Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein
Genes Dev. 2003 17: 3017-3022. Published in Advance December 17, 2003, 10.1101/gad.279003 [Abstract] [Full Text] [PDF]

Edgar M. Pera, Atsushi Ikeda, Edward Eivers, and Eddy M. De Robertis: Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
Genes Dev. 2003 17: 3023-3028. [Abstract] [Full Text] [PDF]

Antonio Cozzio, Emmanuelle Passegué, Paul M. Ayton, Holger Karsunky, Michael L. Cleary, and Irving L. Weissman: Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
Genes Dev. 2003 17: 3029-3035. [Abstract] [Full Text] [PDF]

Research Papers:

Åsa Wallén-Mackenzie, Alexander Mata de Urquiza, Susanna Petersson, Francisco J. Rodriguez, Stina Friling, Joseph Wagner, Peter Ordentlich, Johan Lengqvist, Richard A. Heyman, Ernest Arenas, and Thomas Perlmann: Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells
Genes Dev. 2003 17: 3036-3047. Published in Advance December 17, 2003, 10.1101/gad.276003 [Abstract] [Full Text] [PDF]

Gergana Dobreva, Julia Dambacher, and Rudolf Grosschedl: SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin µ gene expression
Genes Dev. 2003 17: 3048-3061. [Abstract] [Full Text] [PDF]

Jianping Jin, Takahiro Shirogane, Lai Xu, Grzegorz Nalepa, Jun Qin, Stephen J. Elledge, and J. Wade Harper: SCF^-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
Genes Dev. 2003 17: 3062-3074. Published in Advance December 17, 2003, 10.1101/gad.1157503 [Abstract] [Full Text] [PDF]

Li Jin, Brian W. Guzik, Yeou-cherng Bor, David Rekosh, and Marie-Louise Hammarskjöld: Tap and NXT promote translation of unspliced mRNA
Genes Dev. 2003 17: 3075-3086. [Abstract] [Full Text] [PDF]

Eldad Tzahor, Hervé Kempf, Roy C. Mootoosamy, Andy C. Poon, Arhat Abzhanov, Clifford J. Tabin, Susanne Dietrich, and Andrew B. Lassar: Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle
Genes Dev. 2003 17: 3087-3099. [Abstract] [Full Text] [PDF]

Xantha Karp and Iva Greenwald: Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans
Genes Dev. 2003 17: 3100-3111. [Abstract] [Full Text] [PDF]

Andrew J. Aguirre, Nabeel Bardeesy, Manisha Sinha, Lyle Lopez, David A. Tuveson, James Horner, Mark S. Redston, and Ronald A. DePinho: Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
Genes Dev. 2003 17: 3112-3126. Published in Advance December 17, 2003, 10.1101/gad.1158703 [Abstract] [Full Text] [PDF] Supplemental Research Data

Brian C. Lewis, David S. Klimstra, and Harold E. Varmus: The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer
Genes Dev. 2003 17: 3127-3138. Published in Advance December 17, 2003, 10.1101/gad.1140403 [Abstract] [Full Text] [PDF]

Cover Caption:

Cover Cover A mouse model of pancreatic ductal adenocarcinoma that recapitulates the genetics and pathology of the human disease. Shown here is a hematoxylin and eosin-stained photomicrograph of a pancreatic adenocarcinoma occurring in a 10-wk-old mouse with pancreas-specific activation of oncogenic Kras and homozygous deletion of the Ink4a/Arf tumor suppressor locus. This tumor (lower-left half of image) has invaded through the intestinal muscle wall (highlighted circle) and into the adjacent intestinal epithelium (upper right). The inset panels depict the age-dependent onset and progression of these malignancies:The mice first develop multifocal low-grade pancreatic intraepithelial neoplasia (PanIN, left). These lesions progress to higher-grade PanIN structures (middle) and eventually to invasive and metastatic cancers (right ). (For details, see Aguirre et al., p. 3112, and the related paper by Lewis et al., p. 3127.)