Genes & Development -- Table of Contents (February 15 2003, 17 [4])

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Volume 17, Issue 4: February 15, 2003 [Index by Author] [Cover Caption]

Other Issues:

Reviews

Research Communications

Research Papers

Errata

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Reviews:

Nuno André Faustino and Thomas A. Cooper: Pre-mRNA splicing and human disease
Genes Dev. 2003 17: 419-437. [Full Text] [PDF]

Research Communications:

John G. Doench, Christian P. Petersen, and Phillip A. Sharp: siRNAs can function as miRNAs
Genes Dev. 2003 17: 438-442. [Abstract] [Full Text] [PDF]

Joris Pothof, Gijs van Haaften, Karen Thijssen, Ravi S. Kamath, Andrew G. Fraser, Julie Ahringer, Ronald H.A. Plasterk, and Marcel Tijsterman: Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi
Genes Dev. 2003 17: 443-448. Published in Advance January 31, 2003, 10.1101/gad.1060703 [Abstract] [Full Text] [PDF]

Karen Cichowski, Sabrina Santiago, Melanie Jardim, Bryan W. Johnson, and Tyler Jacks: Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor
Genes Dev. 2003 17: 449-454. Published in Advance January 31, 2003, 10.1101/gad.1054703 [Abstract] [Full Text] [PDF]

Oxana A. Malakhova, Ming Yan, Michael P. Malakhov, Youzhong Yuan, Kenneth J. Ritchie, Keun Il Kim, Luke F. Peterson, Ke Shuai, and Dong-Er Zhang: Protein ISGylation modulates the JAK-STAT signaling pathway
Genes Dev. 2003 17: 455-460. Published in Advance January 31, 2003, 10.1101/gad.1056303 [Abstract] [Full Text] [PDF]

Research Papers:

Blair R. Szymczyna, John Bowman, Susan McCracken, Antonio Pineda-Lucena, Ying Lu, Brian Cox, Mark Lambermon, Brenton R. Graveley, Cheryl H. Arrowsmith, and Benjamin J. Blencowe: Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing
Genes Dev. 2003 17: 461-475. [Abstract] [Full Text] [PDF]

Rebecca M. Wolf, Nicole Draghi, Xiquan Liang, Chengkai Dai, Lene Uhrbom, Charlotta Eklöf, Bengt Westermark, Eric C. Holland, and Marilyn D. Resh: p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human Chromosome 19q13.3
Genes Dev. 2003 17: 476-487. [Abstract] [Full Text] [PDF]

Edward J. Gunther, Susan E. Moody, George K. Belka, Kristina T. Hahn, Nathalie Innocent, Katherine D. Dugan, Robert D. Cardiff, and Lewis A. Chodosh: Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis
Genes Dev. 2003 17: 488-501. [Abstract] [Full Text] [PDF]

Vishva Mitra Sharma, Bing Li, and Joseph C. Reese: SWI/SNF-dependent chromatin remodeling of RNR3 requires TAF_IIs and the general transcription machinery
Genes Dev. 2003 17: 502-515. [Abstract] [Full Text] [PDF] Supplemental Research Data

Sang-Gun Ahn and Dennis J. Thiele: Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress
Genes Dev. 2003 17: 516-528. [Abstract] [Full Text] [PDF]

John L. Rinn, Ghia Euskirchen, Paul Bertone, Rebecca Martone, Nicholas M. Luscombe, Stephen Hartman, Paul M. Harrison, F. Kenneth Nelson, Perry Miller, Mark Gerstein, Sherman Weissman, and Michael Snyder: The transcriptional activity of human Chromosome 22
Genes Dev. 2003 17: 529-540. [Abstract] [Full Text] [PDF]

Errata:

: Errata for vol. 17, p. 88
Genes Dev. 2003 17: 541. [Full Text] [PDF]

Cover Caption:

Cover

The PWI motif is a highly conserved nucleic-acid-binding domain found in several pre-mRNA processing components. Shown hereis a ribbon representation of the solution structure of the PWImotif of SRm160 (the SR-related nuclear matrix protein of 160kD). The motif is composed of an $alpha$ -helical bundle, which cooperateswith an adjacent basic domain (not shown) to provide stable bindingto nucleic acids. In addition to its function in splicing, Srm160(blue oval) also stimulates cleavage by the 3'-end processingmachinery (green oval). The RNA-binding activity of the SRm160PWI domain is important for its 3'-end cleavage-stimulatory function.(For details, see Szymczyna et al., p. 461.)