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Meiotic progression in Exo1 mutant female oocytes. Shown here are chromosome spreads from oocytes taken from Exo1
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females at day 2 postpartum. Oocytes progress through early prophase I of meiosis, as demonstrated by complete pairing of homologous chromosomes and residual Dmc1/Rad51 foci (green) at early pachynema (inset image; centromeres in blue), and into early diplotene (not shown). The oocytes then enter dictyate arrest (background image), as demonstrated by the gradual degradation of chromosomal cores, but persistence of Cor1 (red). However, despite this normal progression through prophase I, the resulting oocytes are not capable of postfertilization development, and the mice are infertile. (For details, see Wei et al., p. 603.)