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T-cell homeostasis is disrupted in tcasp8^/ mice carrying a T-cell-specific caspase 8 mutation. Shown here is immunohistochemical staining of T-cells (anti-CD3, pink staining) and B-cells (anti-B220, brown staining) in spleen sections from tcasp8^/ (inset) and wild-type (background) mice. The total number of T-cells is significantly decreased in spleens from tcasp8^\ mice compared to control littermates. (For details, see Salmena et al., p. 883.)