|
|
|
![]() Other Issues: |
|
||||||
The NF2 tumor suppressor protein, merlin, localizes to adherens junctions in mammalian cells. Shown here is the subcellular localization pattern of a mutant merlin-GFP fusion protein (GFP-Nf2L64P; green) in primary epithelial mouse keratinocytes, in which the nuclei are stained with DAPI (blue). Whereas a wild-type GFP-Nf2 fusion protein colocalizes with adherens junctions components at the cell:cell boundaries, GFP-Nf2L64P exhibits punctate distribution throughout the cytoplasm. (For details, see Lallemand et al., p. 1090.)