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The NF2 tumor suppressor protein, merlin, localizes to adherens junctions in mammalian cells. Shown here is the subcellular localization pattern of a mutant merlin-GFP fusion protein (GFP-Nf2^L64P; green) in primary epithelial mouse keratinocytes, in which the nuclei are stained with DAPI (blue). Whereas a wild-type GFP-Nf2 fusion protein colocalizes with adherens junctions components at the cell:cell boundaries, GFP-Nf2^L64P exhibits punctate distribution throughout the cytoplasm. (For details, see Lallemand et al., p. 1090.)