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Cover Epithelial hyperplasia with maintenance of spatially correct differentiation in RelA-/- epidermis. Shown here is an immunohistochemical stain of epidermis deficient in the RelA subunit of NF-KB. Despite markedly increased cell numbers (Hoechst 33342 nuclear stain, blue), the keratin 10 differentiation marker (green) is appropriately expressed in suprabasal differentiating layers of cells above the basement membrane zone (laminin 5, orange). In epidermis, RelA is dispensable for differentiation while antagonizing TNFR1-JNK proliferative signals in epidermis and plays a nonredundant role in restraining epidermal growth. (For details, see Zhang et al., p. 17.)