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Cover iguana is required for Hedgehog signal transduction in the zebrafish embryo. Shown here is an immunofluorescence analysis of the developing myotome in a wild-type (upper) and iguana mutant (lower) zebrafish embryo. Muscle cells that express the homeodomain-containing proteins Engrailed (red), or Prox1 (green) as well as Engrailed, are induced by distinct threshold levels and timing of Hedgehog signaling activity. Loss of the iguana gene function results in a dramatic alteration of the pattern of Engrailed expression within the myotome. iguana encodes a novel component of the Hedgehog signal transduction pathway that regulates the nuclear activities of the Gli transcription factors. (For details, see Wolff et al., p.1565.)

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