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Cover The activity of Drosophila nitric-oxide synthase (DNOS) is controlled during development by endogenously produced truncated DNOS isoforms. Shown here is an immunocytochemical analysis of a third-instar wing disc, using antibodies directed against DNOS1 (green), a full-length enzymatically active protein, and DNOS4 (red), a shorter isoform that acts as a dominant negative regulator of DNOS1. When DNOS4 suppresses the antiproliferative activity of DNOS1 in imaginal discs, there is an increase in the number of cells in the adult structures. (For details, see Stasiv et al., p.1812.)

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