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Cover Cell proliferation in neuroepithelial rosette-like structures in the brain of Lgl1-knockout mice. Shown here is an immunofluorescence analysis of the developing brain of an Lgl1-null animal at embryonic day 12.5. Newly synthesized DNA was labeled by bromodeoxyuridine (BrdU) 24 h before the analysis. Sections were stained with antibodies directed against BrdU (red) and Ki67 (green). Cells that re-enter cell cycle were labeled with both BrdU and Ki67 antibodies (yellow), while cells withdrawn from cell cycle were labelled by BrdU, but not by Ki67 antibodies (red). (For details, see Klezovitch et al., 559.)