Genes & Development -- Table of Contents (April 1 2004, 18 [7])

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Volume 18, Issue 7: April 1, 2004 [Index by Author] [Cover Caption]

Other Issues:

Reviews

Research Communications

Research Papers

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Reviews:

Michael Ibba and Dieter Söll: Aminoacyl-tRNAs: setting the limits of the genetic code
Genes Dev. 2004 18: 731-738. [Full Text] [PDF]

Research Communications:

Lynne Bemis, Denise A. Chan, Carla V. Finkielstein, Lin Qi, Patrick D. Sutphin, Xiaojiang Chen, Kurt Stenmark, Amato J. Giaccia, and Wayne Zundel: Distinct aerobic and hypoxic mechanisms of HIF- ${alpha}$ regulation by CSN5
Genes Dev. 2004 18: 739-744. [Abstract] [Full Text] [PDF]

Research Papers:

Shang-Yi Chiu, Fabrice Lejeune, Aparna C. Ranganathan, and Lynne E. Maquat: The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex
Genes Dev. 2004 18: 745-754. Published in Advance April 1, 2004, 10.1101/gad.1170204 [Abstract] [Full Text] [PDF]

Jeremy R. Sanford, Nicola K. Gray, Karsten Beckmann, and Javier F. Cáceres: A novel role for shuttling SR proteins in mRNA translation
Genes Dev. 2004 18: 755-768. [Abstract] [Full Text] [PDF] Supplemental Research Data

Donald L. Pappas, Jr., Ryan Frisch, and Michael Weinreich: The NAD⁺-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication
Genes Dev. 2004 18: 769-781. [Abstract] [Full Text] [PDF] Supplemental Research Data

Shin Takeda, Zerihun Tadele, Ingo Hofmann, Aline V. Probst, Karel J. Angelis, Hidetaka Kaya, Takashi Araki, Tesfaye Mengiste, Ortrun Mittelsten Scheid, Kei-ichi Shibahara, Dierk Scheel, and Jerzy Paszkowski: BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis
Genes Dev. 2004 18: 782-793. [Abstract] [Full Text] [PDF]

Sonya Vengrova and Jacob Z. Dalgaard: RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching
Genes Dev. 2004 18: 794-804. Published in Advance April 1, 2004, 10.1101/gad.289404 [Abstract] [Full Text] [PDF] Supplemental Research Data

Joseph A. Brzostowski, Carole A. Parent, and Alan R. Kimmel: A G ${alpha}$ -dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement
Genes Dev. 2004 18: 805-815. Published in Advance April 1, 2004, 10.1101/gad.1173404 [Abstract] [Full Text] [PDF] Supplemental Research Data

Chie Kanei-Ishii, Jun Ninomiya-Tsuji, Jun Tanikawa, Teruaki Nomura, Tohru Ishitani, Satoshi Kishida, Kenji Kokura, Toshihiro Kurahashi, Emi Ichikawa-Iwata, Yongsok Kim, Kunihiro Matsumoto, and Shunsuke Ishii: Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
Genes Dev. 2004 18: 816-829. [Abstract] [Full Text] [PDF] Supplemental Research Data

Vladimir V. Kalinichenko, Michael L. Major, Xinhe Wang, Vladimir Petrovic, Joseph Kuechle, Helena M. Yoder, Margaret B. Dennewitz, Brian Shin, Abhishek Datta, Pradip Raychaudhuri, and Robert H. Costa: Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19^ARF tumor suppressor
Genes Dev. 2004 18: 830-850. [Abstract] [Full Text] [PDF]

Cover Caption:

Cover Cover Multiple signaling pathways that ultimately regulate chemotaxis can be attenuated by a single heterotrimeric Gα protein in Dictyostelium discoideum. Shown here is a composite image of Dictyostelium cells moving toward a pipette (gray) that is emitting a chemoattractant. Relative to wild-type cells (blue), gα9-null cells (green) are hyperpolarized and rarely produce lateral pseudopods, indicative of a loss of a negative regulator of chemotaxis. Cells expressing constitutively activated Gα9 (red) display the expected opposite phenotype, are poorly polarized, and produce numerous lateral pseudopods. In the background, a population of gα9-null cells chemotax to form aggregation centers during development. (For details, see Brzostowski et al., p.805.)