Cover image

Cover Arabidopsis HDA6 is a histone deacetylase, previously implicated in the transcriptional silencing of transposable elements and transgenes, that is also required for nucleolar dominance, the uniparental silencing of ribosomal RNA genes in a genetic hybrid. Shown here is an immunofluorescence image of a leaf cell nucleus expressing Flag-tagged HDA6, stained with antibodies against HDAC6-Flag (red). Nuclear chromatin is counterstained with DAPI (blue). HDA6 is concentrated at multiple foci, the most prominent of which is the DAPI-negative nucleolus (top center), consistent with a role for HDAC6 in nucleolar dominance. Cover image courtesy of Olga Pontes. (For details, see Earley et al., p. 1283.)