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Cover The Drosophila protein GW182 functions in the miRNA pathway and localizes to mRNA processing bodies (P-bodies) together with enzymes involved in mRNA deadenylation and decapping. Shown here are confocal fluorescent micrographs of Drosophila cells expressing the decapping coactivator DCP1 (left, green) or the P-body markers GW182 or Ge-1 (middle, red). Merged images are shown on the right. DNA is stained with DAPI (blue). miRNAs silence gene expression by repressing translation and/or by promoting mRNA degradation, and both mechanisms require GW182. In addition, mRNA degradation by miRNAs involves deadenylation and decapping. (For details, see Behm-Ansmant et al., p. 1885.)

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