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Cover Gli proteins mediate the transcriptional effects of the Sonic hedgehog pathway, which is implicated in up to 25 percent of human tumors. Gli protein is rapidly destroyed by the proteosome via two independent destruction signals (DN and DC), and the onset of mouse basal cell carcinoma induction correlates with the ability of Gli protein to accumulate. Shown here is an immunofluoresence analysis of a mouse basal cell carcinoma expressing exogenous Gli2, using antibodies directed against exogenous Gli2 (red) and the epithelial basement membrane marker laminin 5 (green), with nuclei stained blue. High levels of Gli2 are present in the tumor but not in the interfollicular epithelium. The surrounding basement membrane zone delimits the tumor and epidermis. (For details, see Huntzicker et al., p. 276.)