Cover image

Cover A-type lamins affect myoblasts’ commitment to terminally differentiate. Shown here is an immunofluorescence analysis of a human embryonic skeletal muscle myotube that was formed in vitro and immunostained for lamin A/C (green) and the nucleolar marker fibrillarin (red). DNA was stained with DAPI (blue). The image shows a two-dimensional representation of serial sections taken through the myofiber, displaying the perinucleolar and nuclear envelope localization of A-type lamins. In Lmna mutant mouse muscle cells, differentiation is impaired with few cells forming myotubes. (For details, see Frock et al., p. 486.)