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Cover Several members of the cysteine cathepsin family of proteases have distinct and nonredundant roles in promoting pancreatic islet tumorigenesis. Shown here is an immunofluorescence analysis of the invasive edge of an islet tumor from a mouse model of pancreatic islet carcinoma, using antibodies directed against cathepsin B (green) and E-cadherin (red). DNA was stained with DAPI (blue). Cathepsin B localization correlates with the down-regulation of E-cadherin at the invasive tumor front. Deletion of cathepsin B resulted in maintenance of E-cadherin protein levels, and was associated with a pronounced reduction in tumor invasion in vivo. (For details, see Gocheva et al., p. 543.)