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Cover In the neural retina, the level of SOX2 is critical for normal development. Alterations in SOX2 levels disrupt retinal laminar morphology. Shown here is an immunofluorescence analysis of a Sox2 hypomorphic mutant adult retina expressing EGFP driven by Sox2 regulatory elements (green) and stained with antibodies directed against the retinal ganglion and amacrine cell marker, CALRETININ (red), illustrating aberrant rosette structure formation. (For details, see Taranova et al., p. 1187.)