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Cover A targeted deletion of PPAR. in mice results in the production of “toxic milk” containing elevated levels of inflammatory lipids, which, upon ingestion by nursing neonates, causes inflammation, alopecia, and growth retardation. Shown here is an immunofluorescence analysis of the sagittal sections of dorsal skin of pups nursed by PPARγ-deficient mothers, using antibodies directed against the macrophage cell marker CD11b/Mac-1 (green). DNA was stained with DAPI (blue). There is an increased macrophage infiltration in the inter-follicular region and subcutaneous fat as early as postnatal day 10. Therefore, maternal PPARγ is pivotal for maintaining the quality of milk and protecting the nursing newborns by suppressing the production of inflammatory lipids in the lactating mammary gland. (For details, see Wan et al., p. 1895.)