Cover image

Cover Phr1 regulates mammalian neural development. Shown here are combined images of coronal sections through wild-type (left) and Phr1 mutant (right) murine brains at embryonic day 18.5, using antibodies directed against the corticofugal axon marker, L1 (green), and the thalamic axon marker, Calretinin (red). Sections were stained with Nissl (blue) to visualize neuronal cell bodies. Loss of Phr1 in a targeted knockout mouse results in the failure of both thalamocortical and corticofugal axons to cross into the subpallial telencephalon. (For details, see Bloom et al., p. 2593.)