QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Cover Blocking the activity of the transcription factor NF-κB in the skin of old mice substantially reversed the global gene expression program and tissue characteristics to those of young mice. Shown in the foreground, from left to right, are hematoxylin and eosin-stained skin sections from a newborn mouse, a young mouse, an old mouse, and an old mouse following NF-κB blockade. NF-κB blockade led to decreased cellular senescence and increased proliferation (note the thicker skin), and reversion of the global gene expression program to that resembling young mice. Shown in the background is a microarray analysis of whole skin tissue from an old mouse following NF-κB blockade. (For details, see Adler et al., p. 3244.)