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Cover The Caenorhabditis elegans semaphorin-plexin signaling system regulates cellular morphology via the stimulation of mRNA translation in epidermal ray precursor cells. Shown here is a fluorescence image of a transgenic wild-type male worm expressing an EGFP::unc-54/myosin heavy chain gene 3′UTR reporter construct and a mRFP::unc-60A/cofilin gene 3′UTR reporter construct under the control of the lin-32 promoter in tail ray precursor cells. The epidermal cell boundaries are visualized with the adherens junction marker AJM-1::GFP. Semaphorin signaling simultaneously stimulates global translation and preferential translation of unc-60A via its 3′UTR in ray precursor cells. (For details, see Nukazuka et al., p. 1025.)

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