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Cover A Drosophila model of Ataxia telangiectasia (A-T) reveals that mutations in the cell cycle activator gene String/CDC25 inhibit cell cycle re-entry and neurodegeneration. Shown here is an immunofluorescence analysis of an imaginal eye disc from a fly in which ATM was depleted by RNAi, using antibodies directed against the post-mitotic neuronal marker, Elav (red), and the DNA replication marker, BrdU (green). ATM knockdown disrupts normal cell cycle control and causes post-mitotic neurons to re-enter the cell cycle (yellow). (For details, see Rimkus et al., p. 1205.)